MECHANISM OF ACTION OF BOTULINUM NEUROTOXINS AND THEIR USE IN THE TREATMENT OF SPASTIC DISORDERS

Pubblicazioni Scientifiche

• BIOCHEMICAL JOURNAL

  VESICLE-ASSOCIATED MEMBRANE PROTEIN-2 (SYNAPTOBREVIN-2) FORMS A COMPLEX WITH SYNAPTOPHYSIN

• EMBO JOURNAL

  VAMP-2 AND CELLUBREVIN ARE EXPRESSED IN PANCREATIC BETA-CELLS AND ARE ESSENTIAL FOR CA2+ - BUT NOT FOR GTP-GAMMA-S-INDUCED INSULIN-SECRETION

• EUROPEAN JOURNAL OF BIOCHEMISTRY

  STRUCTURAL STUDIES ON THE ZINC-ENDOPEPTIDASE LIGHT-CHAIN OF TETANUS NEUROTOXIN

• EUROPEAN JOURNAL OF BIOCHEMISTRY

  X-ray absorption spectroscopy study of zinc coordination in tetanus neurotoxin, astacin, alkaline protease and thermolysin

• FEBS LETTERS

  BACTERIAL PROTEIN TOXINS PENETRATE CELLS VIA A 4-STEP MECHANISM

• JOURNAL OF BIOLOGICAL CHEMISTRY

  BOTULINUM NEUROTOXIN TYPE-C CLEAVES A SINGLE LYS-ALA BOND WITHIN THE CARBOXYL-TERMINAL REGION OF SYNTAXINS

• JOURNAL OF BIOLOGICAL CHEMISTRY

  BOTULINUM-G NEUROTOXIN CLEAVES VAMP/SYNAPTOBREVIN AT A SINGLE ALA-ALA PEPTIDE-BOND

• JOURNAL OF BIOLOGICAL CHEMISTRY

  Clostridial neurotoxins and substrate proteolysis in intact neurons - Botulinum neurotoxin C acts on synaptosomal-associated protein of 25 kDa

• JOURNAL OF CELL BIOLOGY

  VAMP synaptobrevin isoforms 1 and 2 are widely and differentially expressed in nonneuronal tissues

• JOURNAL OF PHYSIOLOGY-PARIS

  THE METALLOPROTEINASE ACTIVITY OF TETANUS AND BOTULISM NEUROTOXINS

• MOLECULAR MICROBIOLOGY

  MECHANISM OF ACTION OF TETANUS AND BOTULINUM NEUROTOXINS

• NATURE

  SNARE MOTIF AND NEUROTOXINS

• PROTEOLYTIC ENZYMES: ASPARTIC AND METALLO PEPTIDASES

  TETANUS AND BOTULISM NEUROTOXINS - ISOLATION AND ASSAY

• QUARTERLY REVIEWS OF BIOPHYSICS

  Structure and function of tetanus and botulinum neurotoxins

• TOXINS AND EXOCYTOSIS

  TETANUS AND BOTULINUM NEUROTOXINS ARE ZINC PROTEASES SPECIFIC FOR COMPONENTS OF THE NEUROEXOCYTOSIS APPARATUS