A NOVEL THERAPEUTIC PROTOCOL TO CORRECT MUSCULAR DYSTROPHIES BY ENGINEREED MESOANGIOBLASTS: FROM CHROMATIN SIGNALS TO MUSCLE REGENERATION

Pubblicazioni Scientifiche

• BIOMATERIALS

  Electrospun degradable polyesterurethane membranes: potential scaffolds for skeletal muscle tissue engineering

• CELL DEATH AND DIFFERENTIATION

  Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle

• CIRCULATION RESEARCH

  Msx2 and necdin combined activities are required for smooth muscle differentiation in mesoangioblast stem cells

• DEVELOPMENT

  The Wnt/β-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis

• DEVELOPMENTAL BIOLOGY

  Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway

• DEVELOPMENTAL BIOLOGY

  Intrinsic phenotypic diversity of embryonic and fetal myoblasts is revealed by genome-wide gene expression analysis on purified cells

• EXPERIMENTAL CELL RESEARCH

  Allogeneic mesoangioblasts give rise to alpha-sarcoglycan expressing fibers when transplanted into dystrophic mice

• FASEB JOURNAL

  Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines

• JOURNAL OF CELL BIOLOGY

  Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation

• JOURNAL OF CELL BIOLOGY

  Complete repair of dystrophic skeletal muscle by mesoangioblasts with enhanced migration ability

• JOURNAL OF CELL SCIENCE

  TGFβ/BMP activate the smooth muscle/bone differentiation programs in mesoangioblasts

• JOURNAL OF CLINICAL INVESTIGATION

  Human circulating AC133+ stem cells restore dystrophin expression and ameliorate function in dystrophic skeletal muscle

• MOLECULAR BIOLOGY OF THE CELL

  Vasopressin-dependent myogenic cell differentiation is mediated by both Ca2+/calmodulin-dependent kinase and calcineurin pathways

• NATURE

  Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs

• NATURE CELL BIOLOGY

  Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells

• PLOS ONE

  Magic-Factor 1, a Partial Agonist of Met, Induces Muscle Hypertrophy by Protecting Myogenic Progenitors from Apoptosis

• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

  Body-wide gene therapy of Duchenne muscular dystrophy in the mdx mouse model

• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

  MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle

• SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

  Satellite cells, myoblasts and other occasional myogenic progenitors: Possible origin, phenotypic features and role in muscle regeneration

• STEM CELLS

  Embryonic stem-derived versus somatic neural stem cells: A comparative analysis of their developmental potential and molecular phenotype

• TRENDS IN CARDIOVASCULAR MEDICINE

  A role for msx2 and necdin in smooth muscle differentiation of mesoangioblasts and other mesoderm progenitor cells

• TRENDS IN MOLECULAR MEDICINE

  New therapies for muscular dystrophy: cautious optimism